Donnelly Centre, University of Toronto, Canada

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Elena Kuzmin in the lab.

In the Research Projects section we describe five of our current functional genomics projects:

1. Exploring GIs in Yeast
1. Identifying Differential Essential Genes and Mapping Genetic Interaction Networks in a Set of Wild Yeast Isolates
2. Identifying Bypass Suppressors of Essential Genes and Synthetic Lethal Gene Pairs
3. Integrating Diverse Biological Networks
2. Exploring GIs in a Human Cell Line
1. Mapping a Genetic Network for a Reference Human Cell Line
2. Mapping Genetic Interactions of Human Essential Genes
3. Generating A Mitochondrial Network in Health and Disease
4. Exploring the Biological Role of a Deglycosylase Implicated in a Rare Disease
5. Studying Human Genetic Interactions at the Biobank Level by Using Scalable Algorithms
3. Exploring Chemical Genetics in Yeast and Other Organisms and in a Human Cell Line
1. Applying Chemical Genetic Interactions to Guide Follow-up Characterization of Novel Compounds in Yeast
2. Identifying Novel Bioactivated Drug Leads Against Multiple Human Infectious Diseases
3. Functional Characterization of Chemical-Genetic Interactions
4. Building and Characterizing New Yeast Collections
1. The YETI Collection (Yeast Estradiol strains with Titratable Induction)
2. Constructing Deletion Collections in Natural Yeast Isolates Using CRISPR-Cas9
3. Sequence Analysis of our Temperature-sensitive Mutant Collection and Construction of a GFP-tagged Version of the TS Collection

Pierre Côte on the microscope.