Exploring GIs in Yeast:
Identifying Bypass Suppressors of Essential Genes and Synthetic Lethal Gene Pairs
People
Radha Subramaniam, Clarence Yeung
Genetic modifiers, such as suppressor or enhancer mutations, significantly influence observed characteristics and disease phenotypes. This influence extends to the expression of disease phenotypes in both Mendelian and complex genetic disorders. The manifestation of genetic resilience, as exemplified by individuals harboring mutations associated with severe Mendelian diseases yet remaining clinically unaffected, underscores the impact of background-specific genetic interactions. This project utilizes Saccharomyces cerevisiae, employing an automated, high- throughput yeast genetics platform to systematically analyze bypass suppressor networks across both essential genes and synthetic lethal gene pairs. This will contribute towards building a comprehensive, genome-wide network of suppressor genetic interactions to further our understanding of suppressor genetic networks on a broad scale while addressing questions related to genetic resilience, functional genetic relationships, evolutionary conservation of genetic pathways, and development of therapeutics.
